paweh - Power and Sample Size Analysis for Genetic Studies with Heterogeneity and Misclassification

Provides prospective power and minimum sample size necessary (MSSN) calculations for genetic and genomic association study design. Supported designs include case-control studies, transmission disequilibrium tests with affected-child trios, and single- and multivariate quantitative-trait studies. The package emphasizes selected departures from idealized assumptions, including locus heterogeneity and supported forms of genotype and phenotype misclassification. These factors can materially affect power and sample-size requirements but can be difficult to incorporate analytically. Published statistical-genetics methods are implemented in a reproducible, primarily parameter- and model-based framework with static visualizations and an optional Shiny dashboard for interactive exploration. The software supports prospective study planning; it does not perform downstream association testing.